Transcriptional regulation is insufficient to explain substrate‐induced flux changes in Bacillus subtilis

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Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis

One of the key ways in which microbes are thought to regulate their metabolism is by modulating the availability of enzymes through transcriptional regulation. However, the limited success of efforts to manipulate metabolic fluxes by rewiring the transcriptional network has cast doubt on the idea that transcript abundance controls metabolic fluxes. In this study, we investigate control of metab...

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ژورنال

عنوان ژورنال: Molecular Systems Biology

سال: 2013

ISSN: 1744-4292,1744-4292

DOI: 10.1038/msb.2013.66